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1 INNClassRoute (list)PK parameters= Cmax; Tmax; F: bioavailability; t1/2: half-life; VD: volume of distribution; Cl: clearance; PPB: plasma protein binding;(EQN means that value was calculated using VD=(Cl*t1/2)/0.693)Primary Target and PDB code of Protein-Drug complexTargets from DrugCentral Links
TACRINE DISCONTINUED

TACRINE


ATC N06DA01

NERVOUS SYSTEM
ANTICHOLINESTERASE
CHOLINESTERASE INHIBITOR

ORAL

Tmax 1.5 HOUR

F 17 PERCENT

VD 349 LITER

PPB 55 PERCENT

Cl 218 LITER / HOUR (65 KILOGRAM)

HT 3 HOUR

SOLUBILITY FREELY SOLUBLE IN DISTILLED WATER

CHOLINESTERASE

PDB 2AOW (HISTAMINE METHYLTRANSFERASE (NATURAL VARIANT I105) COMPLEXED WITH THE ACETYLCHOLINESTERASE INHIBITOR AND ALTZHEIMER'S DISEASE DRUG TACRINE)

LIGAND CODE = THA (link to the list of PDB complexes)

Download experimental 3D coordinates of THA with added hydrogens

CHOLINESTERASES ACHE & BCHE INHIBITOR CHEMBL2095233 CHOLINESTERASES ACHE & BCHE P06276 CHOLINESTERASE HOMO SAPIENS ENZYME HYDROLASEANSM (in French)

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