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| 1 | INN | Class | Route (list) | PK parameters= Cmax; Tmax; F: bioavailability; t1/2: half-life; VD: volume of distribution; Cl: clearance; PPB: plasma protein binding;(EQN means that value was calculated using VD=(Cl*t1/2)/0.693) | Primary Target and PDB code of Protein-Drug complex | Targets from DrugCentral | Links | |||
| FOSCARNET
| FOSCARNET | NATURAL MOLECULE (link) ANTIINFECTIVES | INJECTION | Cmax 623 MICROMOLAR VD 33.8 LITER (65 KILOGRAM) PPB 16 PERCENT Cl 7.1 LITER / HOUR HT 3.3 HOUR | DNA POLYMERASE PDB 1NKI (CRYSTAL STRUCTURE OF THE FOSFOMYCIN RESISTANCE PROTEIN A (FOSA) CONTAINING BOUND PHOSPHONOFORMATE) LIGAND CODE = PPF (link to the list of PDB complexes) Download experimental 3D coordinates of PPF with added hydrogens | DNA polymerase catalytic subunit UNIPROT P04293 more at DrugCentral | EMA | |||
