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1 INNClassRoute (list)PK parameters= Cmax; Tmax; F: bioavailability; t1/2: half-life; VD: volume of distribution; Cl: clearance; PPB: plasma protein binding;(EQN means that value was calculated using VD=(Cl*t1/2)/0.693)Primary Target and PDB code of Protein-Drug complexTargets from DrugCentral Links
PAROXETINE

PAROXETINE


ATC N06AB05

NERVOUS SYSTEM
ANTIDEPRESSANTS
SELECTIVE SEROTONIN REUPTAKE INHIBITORS (SSRIS)

ORAL

Cmax 187 NANOMOLAR

Tmax 5.2 HOUR

VD 1170 LITER (65 KILOGRAM)

PPB 94 PERCENT

Cl 70.2 LITER / HOUR (65 KILOGRAM)

HT 21 HOUR

SOLUBILITY OF 5.4 MILLIGRAM / MILLILITER IN WATER

SEROTONIN TRANSPORTER

PDB 6F6I (CRYSTAL STRUCTURE OF EBOLAVIRUS GLYCOPROTEIN IN COMPLEX WITH PAROXETINE)

LIGAND CODE = 8PR (link to the list of PDB complexes)

Download experimental 3D coordinates of 8PR with added hydrogens

Sodium-dependent serotonin transporter UNIPROT P31645 SLC6A4

more at DrugCentral

EMA

ANSM (in French)

Inxight Drugs
Dailymed
Drugs.com

SIDER side effects

Chemical Probes Portal

ChEMBL
BindingDB
DrugBank



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