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1 INNClassRoute (list)PK parameters= Cmax; Tmax; F: bioavailability; t1/2: half-life; VD: volume of distribution; Cl: clearance; PPB: plasma protein binding;(EQN means that value was calculated using VD=(Cl*t1/2)/0.693)Primary Target and PDB code of Protein-Drug complexTargets from DrugCentral Links
ONDANSETRON

ONDANSETRON


ATC A04AA01

METABOLISM
ANTIEMETIC
5-HT3 ANTAGONIST

INJECTION ORAL

Cmax 0.34 MICROMOLAR

VD 107 LITER (65 KILOGRAM)

PPB 73 PERCENT

Cl 24.7 LITER / HOUR (65 KILOGRAM)

HT 3.5 HOUR

SOLUBILITY SOLUBLE IN WATER

5-HYDROXYTRYPTAMINE 3 RECEPTOR

PDB 6W1M (CRYO-EM STRUCTURE OF 5HT3A RECEPTOR IN PRESENCE OF ONDANSETRON)

LIGAND CODE = S87 (link to the list of PDB complexes)

Download experimental 3D coordinates of S87 with added hydrogens

SEROTONIN 3A (5-HT3A) RECEPTOR ANTAGONIST CHEMBL1899 SEROTONIN 3A (5-HT3A) RECEPTOR P46098 5-HYDROXYTRYPTAMINE RECEPTOR 3A HOMO SAPIENS ION CHANNEL LGIC 5HT3ANSM (in French)

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