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1 INNClassRoute (list)PK parameters= Cmax; Tmax; F: bioavailability; t1/2: half-life; VD: volume of distribution; Cl: clearance; PPB: plasma protein binding;(EQN means that value was calculated using VD=(Cl*t1/2)/0.693)Primary Target and PDB code of Protein-Drug complexTargets from DrugCentral Links
TICLOPIDINE (has an active metabolite)

TICLOPIDINE


ATC B01AC05

BLOOD
PLATELET AGGREGATION INHIBITOR
ANTITHROMBOTIC
FIBRINOLYTIC AGENTS
P2Y PURINOCEPTOR 12 ANTAGONIST

ORAL

Tmax 2 HOUR

F 80 PERCENT

PPB 98 PERCENT

HT 108 HOUR

SOLUBILITY FREELY SOLUBLE IN WATER

P2Y PURINOCEPTOR 12

PDB 3KW4 (CRYSTAL STRUCTURE OF CYTOCHROME 2B4 IN COMPLEX WITH THE ANTI-PLATELET DRUG TICLOPIDINE)

LIGAND CODE = TIC (link to the list of PDB complexes)

Download experimental 3D coordinates of TIC with added hydrogens

P2Y purinoceptor 12 UNIPROT Q9H244 P2RY12

more at DrugCentral

EMA

ANSM (in French)

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SIDER side effects

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BindingDB
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