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| 1 | INN | Class | Route (list) | PK parameters= Cmax; Tmax; F: bioavailability; t1/2: half-life; VD: volume of distribution; Cl: clearance; PPB: plasma protein binding;(EQN means that value was calculated using VD=(Cl*t1/2)/0.693) | Primary Target and PDB code of Protein-Drug complex | Targets from DrugCentral | Links | |||
| FLUCONAZOLE
| FLUCONAZOLE |
ANTIINFECTIVES | ORAL INJECTION | Cmax 21.9 MICROMOLAR Tmax 1.5 HOUR F 90 PERCENT VD 48.7 LITER (65 KILOGRAM) PPB 60 PERCENT Cl 0.9 LITER / HOUR (65 KILOGRAM) HT 30 HOUR SOLUBILITY SLIGHTLY SOLUBLE IN WATER | CYTOCHROME P450 51 PDB 2WUZ (X-RAY STRUCTURE OF CYP51 FROM TRYPANOSOMA CRUZI IN COMPLEX WITH FLUCONAZOLE IN ALTERNATIVE CONFORMATION) LIGAND CODE = TPF (link to the list of PDB complexes) Download experimental 3D coordinates of TPF with added hydrogens | Lanosterol 14-alpha demethylase UNIPROT P10613 ERG11 more at DrugCentral | EMA | |||
