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| 1 | INN | Class | Route (list) | PK parameters= Cmax; Tmax; F: bioavailability; t1/2: half-life; VD: volume of distribution; Cl: clearance; PPB: plasma protein binding;(EQN means that value was calculated using VD=(Cl*t1/2)/0.693) | Primary Target and PDB code of Protein-Drug complex | Targets from DrugCentral | Links | |||
| SERTRALINE
| SERTRALINE | NERVOUS SYSTEM | ORAL | Cmax 464 NANOMOLAR Tmax 6.4 HOUR PPB 98 PERCENT HT 26 HOUR SOLUBILITY SLIGHTLY SOLUBLE IN WATER | SEROTONIN TRANSPORTER PDB 6F6N (CRYSTAL STRUCTURE OF EBOLAVIRUS GLYCOPROTEIN IN COMPLEX WITH SERTRALINE) LIGAND CODE = SRE (link to the list of PDB complexes) Download experimental 3D coordinates of SRE with added hydrogens | Sodium-dependent serotonin transporter UNIPROT P31645 SLC6A4 more at DrugCentral | EMA | |||
