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1 INNClassRoute (list)PK parameters= Cmax; Tmax; F: bioavailability; t1/2: half-life; VD: volume of distribution; Cl: clearance; PPB: plasma protein binding;(EQN means that value was calculated using VD=(Cl*t1/2)/0.693)Primary Target and PDB code of Protein-Drug complexTargets from DrugCentral Links
LEVAMLODIPINE

LEVAMLODIPINE
AMLODIPINE


ATC C08CA01
ATC C08GA02
ATC C09XA53
ATC C09XA54
ATC C10BX03
ATC C10BX11
ATC C07FB07
ATC C09DB07
ATC C09DX06
ATC C09DB05
ATC C09BB03
ATC C09DB06
ATC C07FB13
ATC C07FB12
ATC C09DB02
ATC C09DX03
ATC C09BB04
ATC C09BX01
ATC C09BB07
ATC C09BX03
ATC C10BX09
ATC C10BX07
ATC C10BX14
ATC C09DB04
ATC C09DB01
ATC C09DX01
ATC C08CA51
ATC C09DB09
ATC C09DX07
ATC C09BX04

CARDIVASCULAR
CALCIUM CHANNEL BLOCKER
ANTIANGINALS
ANTIHYPERTENSIVE AGENTS
VASODILATOR AGENTS
PYRIDINE CALCIUM ANTAGONIST (CALCIUM ION ANTAGONIST OR SLOW-CHANNEL BLOCKER)

ORAL

Tmax 8 HOUR

F 77 PERCENT

VD 1365 LITER (65 KILOGRAM)

PPB 93 PERCENT

Cl 27.3 LITER / HOUR (65 KILOGRAM)

HT 40 HOUR

SOLUBILITY SLIGHTLY SOLUBLE IN WATER

CALCIUM CHANNEL

PDB 5KMD (STRUCTURE OF CAVAB IN COMPLEX WITH AMLODIPINE)

LIGAND CODE = 6UB (link to the list of PDB complexes)

Download experimental 3D coordinates of 6UB with added hydrogens

VOLTAGE-GATED L-TYPE CALCIUM CHANNEL BLOCKER CHEMBL2095229 VOLTAGE-GATED L-TYPE CALCIUM CHANNEL O60840 VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1F HOMO SAPIENS ION CHANNEL VGC VG CAANSM (in French)

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BindingDB
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