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| 1 | INN | Class | Route (list) | PK parameters= Cmax; Tmax; F: bioavailability; t1/2: half-life; VD: volume of distribution; Cl: clearance; PPB: plasma protein binding;(EQN means that value was calculated using VD=(Cl*t1/2)/0.693) | Primary Target and PDB code of Protein-Drug complex | Targets from DrugCentral | Links | |||
| DIMESNA (is an active metabolite)
| DIMESNA | VARIOUS | - | HT 1.17 HOUR | METABOLITES ACROLEIN AND 4-HYDROXY-IFOSFAMIDE | - more at DrugCentral | EMA | |||
| 2 | INN | Class | Route (list) | PK parameters= Cmax; Tmax; F: bioavailability; t1/2: half-life; VD: volume of distribution; Cl: clearance; PPB: plasma protein binding;(EQN means that value was calculated using VD=(Cl*t1/2)/0.693) | Primary Target and PDB code of Protein-Drug complex | Targets from DrugCentral | Links | |||
| MESNA (has an active metabolite)
| MESNA | NATURAL MOLECULE (link) VARIOUS | INJECTION INTRAVENOUS ORAL | Tmax 2.25 HOUR F 58 PERCENT VD 42.3 LITER (65 KILOGRAM) Cl 79.9 LITER / HOUR (65 KILOGRAM) HT 0.36 HOUR | METABOLITES ACROLEIN AND 4-HYDROXY-IFOSFAMIDE PDB 4RQX (CRYSTAL STRUCTURE OF HUMAN PEROXIREDOXIN 4(THIOREDOXIN PEROXIDASE) WITH MESNA) LIGAND CODE = COM (link to the list of PDB complexes) Download experimental 3D coordinates of COM with added hydrogens | Unknown more at DrugCentral | EMA | |||
