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| 1 | INN | Class | Route (list) | PK parameters= Cmax; Tmax; F: bioavailability; t1/2: half-life; VD: volume of distribution; Cl: clearance; PPB: plasma protein binding;(EQN means that value was calculated using VD=(Cl*t1/2)/0.693) | Primary Target and PDB code of Protein-Drug complex | Targets from DrugCentral | Links | |||
| CLOZAPINE
| CLOZAPINE | NERVOUS SYSTEM | ORAL | Cmax 977 NANOMOLAR Tmax 2.5 HOUR VD 104 LITER (65 KILOGRAM) PPB 97 PERCENT Cl 9.7 LITER / HOUR (65 KILOGRAM) HT 8 HOUR SOLUBILITY VERY SLIGHTLY SOLUBLE IN WATER | DOPAMINE RECEPTOR | D(2) dopamine receptor UNIPROT P14416 DRD2 -- 5-hydroxytryptamine receptor 2A UNIPROT P28223 HTR2A more at DrugCentral | EMA | |||
