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1 INNClassRoute (list)PK parameters= Cmax; Tmax; F: bioavailability; t1/2: half-life; VD: volume of distribution; Cl: clearance; PPB: plasma protein binding;(EQN means that value was calculated using VD=(Cl*t1/2)/0.693)Primary Target and PDB code of Protein-Drug complexTargets from DrugCentral Links
CLOZAPINE

CLOZAPINE


ATC N05AH02

NERVOUS SYSTEM
ANXIOLYTIC
ANTIPSYCHOTIC
DOPAMINE RECEPTOR ANTAGONIST
ADRENERGIC, CHOLINERGIC, HISTAMINERGIC AND SEROTONERGIC RECEPTORS ANTAGONIST

ORAL

Cmax 977 NANOMOLAR

Tmax 2.5 HOUR

VD 104 LITER (65 KILOGRAM)

PPB 97 PERCENT

Cl 9.7 LITER / HOUR (65 KILOGRAM)

HT 8 HOUR

SOLUBILITY VERY SLIGHTLY SOLUBLE IN WATER

DOPAMINE RECEPTOR

DOPAMINE D2 RECEPTOR ANTAGONIST CHEMBL217 DOPAMINE D2 RECEPTOR P14416 D(2) DOPAMINE RECEPTOR HOMO SAPIENS MEMBRANE RECEPTOR 7TM1 SMALLMOL MONOAMINE RECEPTOR DOPAMINE RECEPTORANSM (in French)

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