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| 1 | INN | Class | Route (list) | PK parameters= Cmax; Tmax; F: bioavailability; t1/2: half-life; VD: volume of distribution; Cl: clearance; PPB: plasma protein binding;(EQN means that the equation t1/2 = VD / Cl * 0.693 was used | Primary Target and PDB code of Protein-Drug complex | Targets from DrugCentral | Links | |||
| GANCICLOVIR (is an active metabolite) (has an active metabolite)
| GANCICLOVIR | ANTIINFECTIVES | INJECTION ORAL IMPLANTATION OPHTHALMIC INTRAVENOUS | Cmax 26.7 MICROMOLAR Tmax 2 HOUR VD 45.7 LITER (65 KILOGRAM) PPB 1 PERCENT Cl 11.9 LITER / HOUR HT 3.81 HOUR SOLUBILITY APPROXIMATELY 6 MILLIGRAM / MILLILITER AT 37 DEGREE CELSIUS | THYMIDINE KINASE PDB 1KI2 (THYMIDINE KINASE FROM HERPES SIMPLEX VIRUS TYPE I) LIGAND CODE = GA2 (link to the list of PDB complexes) Download experimental 3D coordinates of GA2 with added hydrogens | DNA polymerase catalytic subunit UNIPROT P04293 more at DrugCentral | EMA | |||
| 2 | INN | Class | Route (list) | PK parameters= Cmax; Tmax; F: bioavailability; t1/2: half-life; VD: volume of distribution; Cl: clearance; PPB: plasma protein binding;(EQN means that the equation t1/2 = VD / Cl * 0.693 was used | Primary Target and PDB code of Protein-Drug complex | Targets from DrugCentral | Links | |||
| M GANCICLOVIR (is an active metabolite)
| GANCICLOVIR | ANTIINFECTIVES | - | DNA polymerase catalytic subunit UNIPROT P04293 more at DrugCentral | EMA | |||||
| 3 | INN | Class | Route (list) | PK parameters= Cmax; Tmax; F: bioavailability; t1/2: half-life; VD: volume of distribution; Cl: clearance; PPB: plasma protein binding;(EQN means that the equation t1/2 = VD / Cl * 0.693 was used | Primary Target and PDB code of Protein-Drug complex | Targets from DrugCentral | Links | |||
| M GANCICLOVIR (is an active metabolite)
| GANCICLOVIR | ANTIINFECTIVES | - | PDB 7AOM (STRUCTURE OF NUDT15 IN COMPLEX WITH GANCICLOVIR TRIPHOSPHATE) LIGAND CODE = RQ2 (link to the list of PDB complexes) Download experimental 3D coordinates of RQ2 with added hydrogens | DNA polymerase catalytic subunit UNIPROT P04293 more at DrugCentral | EMA | ||||
| 4 | INN | Class | Route (list) | PK parameters= Cmax; Tmax; F: bioavailability; t1/2: half-life; VD: volume of distribution; Cl: clearance; PPB: plasma protein binding;(EQN means that the equation t1/2 = VD / Cl * 0.693 was used | Primary Target and PDB code of Protein-Drug complex | Targets from DrugCentral | Links | |||
| VALGANCICLOVIR (has an active metabolite)
| VALGANCICLOVIR | ANTIINFECTIVE | ORAL | F 60 PERCENT SOLUBILITY SOLUBILITY OF 70 MILLIGRAM / MILLILITER IN WATER AT 25 DEGREE CELSIUS AT A PH 7.0 | DNA polymerase catalytic subunit UNIPROT P04293 more at DrugCentral | EMA | ||||
| 5 | INN | Class | Route (list) | PK parameters= Cmax; Tmax; F: bioavailability; t1/2: half-life; VD: volume of distribution; Cl: clearance; PPB: plasma protein binding;(EQN means that the equation t1/2 = VD / Cl * 0.693 was used | Primary Target and PDB code of Protein-Drug complex | Targets from DrugCentral | Links | |||
| VALGANCICLOVIR (has an active metabolite)
| VALGANCICLOVIR | ANTIINFECTIVE | ORAL | F 60 PERCENT SOLUBILITY SOLUBILITY OF 70 MILLIGRAM / MILLILITER IN WATER AT 25 DEGREE CELSIUS AT A PH 7.0 | PDB 6GS4 (CRYSTAL STRUCTURE OF PEPTIDE TRANSPORTER DTPA-NANOBODY IN COMPLEX WITH VALGANCICLOVIR) LIGAND CODE = F9E (link to the list of PDB complexes) Download experimental 3D coordinates of F9E with added hydrogens | DNA polymerase catalytic subunit UNIPROT P04293 more at DrugCentral | EMA | |||
