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1 INNClassRoute (list)PK parameters= Cmax; Tmax; F: bioavailability; t1/2: half-life; VD: volume of distribution; Cl: clearance; PPB: plasma protein binding;(EQN means that value was calculated using VD=(Cl*t1/2)/0.693)Primary Target and PDB code of Protein-Drug complexTargets from DrugCentral Links
ZIDOVUDINE

ZIDOVUDINE


ATC J05AF01
ATC J05AR01
ATC J05AR04
ATC J05AR05

ANTIINFECTIVES
ANTIVIRAL
ANTI-HIV
ANTIMETABOLITES
NUCLEOSIDE AND NUCLEOTIDE REVERSE TRANSCRIPTASE (GAG-POL POLYPROTEIN) INHIBITORS

ORAL INJECTION

Tmax 1 HOUR

F 60 PERCENT

VD 104 LITER (65 KILOGRAM)

PPB 38 PERCENT

Cl 104 LITER / HOUR (65 KILOGRAM)

HT 1.75 HOUR

SOLUBILITY OF 20.1 MILLIGRAM / MILLILITER IN WATER AT 25 DEGREE C

HIV REVERSE TRANSCRIPTASE

PDB 3B9L (HUMAN SERUM ALBUMIN COMPLEXED WITH MYRISTATE AND AZT)

LIGAND CODE = AZZ (link to the list of PDB complexes)

Download experimental 3D coordinates of AZZ with added hydrogens

GAG-PRO-POL POLYPROTEIN P03362 GAG-PRO-POL POLYPROTEIN HUMAN T-CELL LEUKEMIA VIRUS 1 (STRAIN JAPAN ATK-1 SUBTYPE A) UNCLASSIFIEDANSM (in French)

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SIDER side effects

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ChEMBL
BindingDB
DrugBank



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