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| 1 | INN | Class | Route (list) | PK parameters= Cmax; Tmax; F: bioavailability; t1/2: half-life; VD: volume of distribution; Cl: clearance; PPB: plasma protein binding;(EQN means that value was calculated using VD=(Cl*t1/2)/0.693) | Primary Target and PDB code of Protein-Drug complex | Targets from DrugCentral | Links | |||
| ZIDOVUDINE
| ZIDOVUDINE |
ANTIINFECTIVES | ORAL INJECTION | Tmax 1 HOUR F 60 PERCENT VD 104 LITER (65 KILOGRAM) PPB 38 PERCENT Cl 104 LITER / HOUR (65 KILOGRAM) HT 1.75 HOUR SOLUBILITY OF 20.1 MILLIGRAM / MILLILITER IN WATER AT 25 DEGREE C | HIV REVERSE TRANSCRIPTASE PDB 3B9L (HUMAN SERUM ALBUMIN COMPLEXED WITH MYRISTATE AND AZT) LIGAND CODE = AZZ (link to the list of PDB complexes) Download experimental 3D coordinates of AZZ with added hydrogens | Reverse transcriptase,RNaseH UNIPROT Q72547 pol more at DrugCentral | EMA | |||
