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1 INNClassRoute (list)PK parameters= Cmax; Tmax; F: bioavailability; t1/2: half-life; VD: volume of distribution; Cl: clearance; PPB: plasma protein binding;(EQN means that value was calculated using VD=(Cl*t1/2)/0.693)Primary Target and PDB code of Protein-Drug complexTargets from DrugCentral Links
RIMANTADINE

RIMANTADINE


ATC J05AC02

ANTIINFECTIVES
ANTIVIRAL
ANTI INFLUENZA A
RESISTANCE OBSERVED
CHANNEL BLOCKER

ORAL

Cmax 510 NANOMOLAR

VD 219 LITER (EQN)

PPB 40 PERCENT

Cl 3.9 LITER / HOUR

HT 39 HOUR

SOLUBILITY SOLUBLE IN WATER (50 MILLIGRAM / MILLILITER)

PROTON TRANSPORTER M2 (PMID23480101)

PDB 2RLF (PROTON CHANNEL M2 FROM INFLUENZA A IN COMPLEX WITH INHIBITOR RIMANTADINE)

LIGAND CODE = RIM (link to the list of PDB complexes)

Download experimental 3D coordinates of RIM with added hydrogens

INFLUENZA VIRUS A MATRIX PROTEIN M2 INHIBITOR CHEMBL2052 INFLUENZA VIRUS A MATRIX PROTEIN M2 P63231 MATRIX PROTEIN 2 INFLUENZA A VIRUS (A/UDORN/307/1972(H3N2)) ION CHANNEL OTHER MISC M2-CANSM (in French)

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