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1 INNClassRoute (list)PK parameters= Cmax; Tmax; F: bioavailability; t1/2: half-life; VD: volume of distribution; Cl: clearance; PPB: plasma protein binding;(EQN means that value was calculated using VD=(Cl*t1/2)/0.693)Primary Target and PDB code of Protein-Drug complexTargets from DrugCentral Links
KETOROLAC

KETOROLAC


ATC M01AB15
ATC S01BC05
ATC S01FB51

MUSCULO-SKELETAL
NONSTEROIDAL ANTIINFLAMMATORY
ANALGESIC
CYCLOOXYGENASE INHIBITORS

ORAL INJECTION OPHTHALMIC NASAL IRRIGATION

Cmax 9.3 MICROMOLAR (30 MG IM)

Tmax 0.75 HOUR

F 100 PERCENT

VD 13 LITER

PPB 99 PERCENT

Cl 13.6 LITER / HOUR (65 KILOGRAM)

HT 5 HOUR

SOLUBILITY SOLUBLE IN WATER

PROSTAGLANDIN G/H SYNTHASE 1
PROSTAGLANDIN G/H SYNTHASE 2

PDB 2MJI (HIFABP_KETOROLAC_COMPLEX)

LIGAND CODE = KTR (link to the list of PDB complexes)

Download experimental 3D coordinates of KTR with added hydrogens

CYCLOOXYGENASE INHIBITOR CHEMBL2094253 CYCLOOXYGENASE P23219 PROSTAGLANDIN G/H SYNTHASE 1 HOMO SAPIENS ENZYME REDUCTASEANSM (in French)

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