Cheminformatic Tools and Databases for Pharmacology

session 70669 - Total of 1 hits - Display   hits per page:

Add another drug(s) by one keyword:
Exemple: “nib“ and click on the Search button (do not press Enter on the keyboard)

1 INNClassRoute (list)PK parameters= Cmax; Tmax; F: bioavailability; t1/2: half-life; VD: volume of distribution; Cl: clearance; PPB: plasma protein binding;(EQN means that value was calculated using VD=(Cl*t1/2)/0.693)Primary Target and PDB code of Protein-Drug complexTargets from DrugCentral Links
PROPOFOL (is an active metabolite)

PROPOFOL


ATC N01AX10

NERVOUS SYSTEM
ANESTHETIC
ANTICONVULSANTS
ANTIEMETICS
FREE RADICAL SCAVENGERS
HYPNOTICS
SEDATIVES
GABA-A AGONIST

INJECTION

Cmax 21.9 MICROMOLAR (18 MILLIGRAM/KG)

VD 305 LITER (65 KILOGRAM)

PPB 98 PERCENT

Cl 150 LITER / HOUR

HT 3.2 HOUR

SOLUBILITY SLIGHTLY SOLUBLE IN WATER

GAMMA-AMINOBUTYRIC-ACID RECEPTOR SUBUNIT ALPHA-1 (GABA(A))
BETA-ADRENOCEPTOR (BETA-AR) (PMID21793316)

PDB 5MVN (X-RAY STRUCTURE OF THE M205W MUTANT OF GLIC IN COMPLEX WITH PROPOFOL)

LIGAND CODE = PFL (link to the list of PDB complexes)

Download experimental 3D coordinates of PFL with added hydrogens

GABA-A RECEPTOR ANION CHANNEL POSITIVE ALLOSTERIC MODULATOR CHEMBL2093872 GABA-A RECEPTOR ANION CHANNEL O00591 GAMMA-AMINOBUTYRIC ACID RECEPTOR SUBUNIT PI HOMO SAPIENS ION CHANNEL LGIC GABAAANSM (in French)

Dailymed
Drugs.com

SIDER side effects

Chemical Probes Portal

ChEMBL
BindingDB
DrugBank



Copyright © 2019 Université Côte d'Azur CNRS - All rights reserved
  | Contact |