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| 1 | INN | Class | Route (list) | PK parameters= Cmax; Tmax; F: bioavailability; t1/2: half-life; VD: volume of distribution; Cl: clearance; PPB: plasma protein binding;(EQN means that value was calculated using VD=(Cl*t1/2)/0.693) | Primary Target and PDB code of Protein-Drug complex | Targets from DrugCentral | Links | |||
| CIPROFLOXACIN
| CIPROFLOXACIN |
ANTIINFECTIVES | ORAL INJECTION OPHTHALMIC OTIC | Cmax 16.3 MICROMOLAR (1000 MILLIGRAM) Tmax 1.5 HOUR F 70 PERCENT VD 156 LITER (65 KILOGRAM) PPB 30 PERCENT Cl 35 LITER / HOUR HT 4 HOUR | DNA GYRASE TOPOISOMERASE 4 PDB 2XCT (THE TWINNED 3.35A STRUCTURE OF S. AUREUS GYRASE COMPLEX WITH CIPROFLOXACIN AND DNA) LIGAND CODE = CPF (link to the list of PDB complexes) Download experimental 3D coordinates of CPF with added hydrogens | DNA gyrase subunit A UNIPROT P0AES4 gyrA more at DrugCentral | EMA | |||
