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1 INNClassRoute (list)PK parameters= Cmax; Tmax; F: bioavailability; t1/2: half-life; VD: volume of distribution; Cl: clearance; PPB: plasma protein binding;(EQN means that value was calculated using VD=(Cl*t1/2)/0.693)Primary Target and PDB code of Protein-Drug complexTargets from DrugCentral Links
FAMOTIDINE

FAMOTIDINE


ATC A02BA03
ATC A02BA53

METABOLISM
HISTAMINE H2 RECEPTOR ANTAGONIST
ANTIHISTAMINE
TREATMENT OF ACTIVE DUODENAL ULCER, GASTRIC ULCER AND GASTROESOPHAGEAL REFLUX DISEASE

ORAL INJECTION

Cmax 181 NANOMOLAR

Tmax 2 HOUR

F 45 PERCENT

VD 84.5 LITER (65 KILOGRAM)

PPB 17 PERCENT

Cl 25.3 LITER / HOUR (65 KILOGRAM)

HT 2.8 HOUR

SOLUBILITY VERY SLIGHTLY SOLUBLE IN WATER

HISTAMINE H2 RECEPTOR

HISTAMINE H2 RECEPTOR ANTAGONIST CHEMBL1941 HISTAMINE H2 RECEPTOR P25021 HISTAMINE H2 RECEPTOR HOMO SAPIENS MEMBRANE RECEPTOR 7TM1 SMALLMOL MONOAMINE RECEPTOR HISTAMINE RECEPTORANSM (in French)

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