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| 1 | INN | Class | Route (list) | PK parameters= Cmax; Tmax; F: bioavailability; t1/2: half-life; VD: volume of distribution; Cl: clearance; PPB: plasma protein binding;(EQN means that value was calculated using VD=(Cl*t1/2)/0.693) | Primary Target and PDB code of Protein-Drug complex | Targets from DrugCentral | Links | |||
| TRANEXAMIC ACID
| TRANEXAMIC ACID | BLOOD | ORAL INJECTION INTRAVENOUS | Cmax 104 MICROMOLAR (MULTIPLE DOSE) Tmax 3 HOUR F 45 PERCENT VD 25.3 LITER (65 KILOGRAM) PPB 3 PERCENT Cl 6.7 LITER / HOUR HT 11 HOUR SOLUBILITY FREELY SOLUBLE IN WATER | PLASMINOGEN PDB 1B2I (KRINGLE 2 DOMAIN OF HUMAN PLASMINOGEN: NMR SOLUTION STRUCTURE OF TRANS-4-AMINOMETHYLCYCLOHEXANE-1-CARBOXYLIC ACID (AMCHA) COMPLEX) LIGAND CODE = AMH (link to the list of PDB complexes) Download experimental 3D coordinates of AMH with added hydrogens | Plasminogen UNIPROT P00747 PLG more at DrugCentral | EMA | |||
