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1 INNClassRoute (list)PK parameters= Cmax; Tmax; F: bioavailability; t1/2: half-life; VD: volume of distribution; Cl: clearance; PPB: plasma protein binding;(EQN means that value was calculated using VD=(Cl*t1/2)/0.693)Primary Target and PDB code of Protein-Drug complexTargets from DrugCentral Links
GUANFACINE

GUANFACINE


ATC C02AC02

CARDIOVASCULAR
ANTIHYPERTENSIVE
ADRENERGIC ALPHA 2 AGONIST
SYMPATHOLYTICS
TREATMENT OF ATTENTION DEFICIT HYPERACTIVITY DISORDER (ADHD)

ORAL

Cmax 10.1 NANOMOLAR

Tmax 3 HOUR

VD 364 LITER (65 KILOGRAM)

PPB 70 PERCENT

Cl 17.5 LITER / HOUR (65 KILOGRAM)

HT 16 HOUR

SOLUBILITY SPARINGLY SOLUBLE IN WATER

ALPHA-2A ADRENERGIC RECEPTOR

ADRENERGIC RECEPTOR ALPHA-2 AGONIST CHEMBL2095158 ADRENERGIC RECEPTOR ALPHA-2 P08913 ALPHA-2A ADRENERGIC RECEPTOR HOMO SAPIENS MEMBRANE RECEPTOR 7TM1 SMALLMOL MONOAMINE RECEPTOR ADRENERGIC RECEPTORANSM (in French)

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