| | ||||||||||
| 1 | INN | Class | Route (list) | PK parameters= Cmax; Tmax; F: bioavailability; t1/2: half-life; VD: volume of distribution; Cl: clearance; PPB: plasma protein binding;(EQN means that value was calculated using VD=(Cl*t1/2)/0.693) | Primary Target and PDB code of Protein-Drug complex | Targets from DrugCentral | Links | |||
| AMIODARONE
| AMIODARONE | CARDIOVASCULAR | ORAL INJECTION | Cmax 40 NANOMOLAR Tmax 5 HOUR F 50 PERCENT VD 3900 LITER (65 KILOGRAM) PPB 96 PERCENT Cl 21.4 LITER / HOUR (65 KILOGRAM) HT 1392 HOUR SOLUBILITY SLIGHTLY SOLUBLE IN WATER | SODIUM CHANNEL POTASSIUM CHANNEL PDB 4O8Z (CRYSTAL STRUCTURE OF HUMAN SIRT3 IN COMPLEX WITH COMPOUND (2-BUTYLBENZOFURAN-3-YL)(4-(2-(DIETHYLAMINO)ETHOXY)-3,5-DIIODOPHENYL)METHANONE) LIGAND CODE = BBI (link to the list of PDB complexes) Download experimental 3D coordinates of BBI with added hydrogens | Potassium voltage-gated channel subfamily H member 2 UNIPROT Q12809 KCNH2 more at DrugCentral | EMA | |||
