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1 INNClassRoute (list)PK parameters= Cmax; Tmax; F: bioavailability; t1/2: half-life; VD: volume of distribution; Cl: clearance; PPB: plasma protein binding;(EQN means that value was calculated using VD=(Cl*t1/2)/0.693)Primary Target and PDB code of Protein-Drug complexTargets from DrugCentral Links
RIBAVIRIN

RIBAVIRIN


ATC J05AB04
ATC J05AP01

ANTIINFECTIVES
ANTIVIRAL
ANTIMETABOLITES
TREATMENT OF CHRONIC HEPATITIS C

INHALATION ORAL

Cmax 3.5 MICROMOLAR

Tmax 1.7 HOUR

F 64 PERCENT

VD 2825 LITER

PPB 0 PERCENT

Cl 38.2 LITER / HOUR

HT 43.6 HOUR

SOLUBILITY FREELY SOLUBLE IN WATER

ADENOSINE KINASE
CYTOSOLIC PURINE 5'-NUCLEOTIDASE
RNA-DIRECTED RNA POLYMERASE CATALYTIC SUBUNIT
ECTONUCLEOTIDE PYROPHOSPHATASE/PHOSPHODIESTERASE FAMILY MEMBER 1
LARGE STRUCTURAL PROTEIN
INOSINE-5'-MONOPHOSPHATE DEHYDROGENASE 1
DNA

PDB 3SFU (CRYSTAL STRUCTURE OF MURINE NOROVIRUS RNA DEPENDENT RNA POLYMERASE IN COMPLEX WITH RIBAVIRIN)

LIGAND CODE = RBV (link to the list of PDB complexes)

Download experimental 3D coordinates of RBV with added hydrogens

INOSINE-5'-MONOPHOSPHATE DEHYDROGENASE 1 INHIBITOR CHEMBL1822 INOSINE-5'-MONOPHOSPHATE DEHYDROGENASE 1 P20839 INOSINE-5'-MONOPHOSPHATE DEHYDROGENASE 1 HOMO SAPIENS ENZYME REDUCTASEANSM (in French)

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