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| 1 | INN | Class | Route (list) | PK parameters= Cmax; Tmax; F: bioavailability; t1/2: half-life; VD: volume of distribution; Cl: clearance; PPB: plasma protein binding;(EQN means that value was calculated using VD=(Cl*t1/2)/0.693) | Primary Target and PDB code of Protein-Drug complex | Targets from DrugCentral | Links | |||
| OXAPROZIN
| OXAPROZIN | MUSCULO-SKELETAL | ORAL | Tmax 3 HOUR F 95 PERCENT VD 10.8 LITER (65 KILOGRAM) PPB 99 PERCENT Cl 0.14 LITER / HOUR (65 KILOGRAM) HT 54.9 HOUR SOLUBILITY INSOLUBLE IN WATER | PDB 7XC4 (CRYSTAL STRUCTURE OF SARS-COV-2 NSP3 MACRODOMAIN 3 (SARS-UNIQUE DOMAIN-M) IN COMPLEX WITH OXAPROZIN) LIGAND CODE = BJ6 (link to the list of PDB complexes) Download experimental 3D coordinates of BJ6 with added hydrogens | Prostaglandin G,H synthase 2 UNIPROT P35354 PTGS2 -- Prostaglandin G,H synthase 1 UNIPROT P23219 PTGS1 more at DrugCentral | EMA | |||
