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| 1 | INN | Class | Route (list) | PK parameters= Cmax; Tmax; F: bioavailability; t1/2: half-life; VD: volume of distribution; Cl: clearance; PPB: plasma protein binding;(EQN means that value was calculated using VD=(Cl*t1/2)/0.693) | Primary Target and PDB code of Protein-Drug complex | Targets from DrugCentral | Links | |||
| ETOPOSIDE (is an active metabolite)
| ETOPOSIDE | ANTINEOPLASTIC | INJECTION ORAL | Cmax 34 MICROMOLAR VD 23.5 LITER PPB 88 PERCENT Cl 2.4 LITER / HOUR HT 7.5 HOUR | DNA TOPOISOMERASE 2 PDB 5CDN (2.8A STRUCTURE OF ETOPOSIDE WITH S.AUREUS DNA GYRASE AND DNA) LIGAND CODE = EVP (link to the list of PDB complexes) Download experimental 3D coordinates of EVP with added hydrogens | DNA topoisomerase 2-alpha UNIPROT P11388 TOP2A more at DrugCentral | EMA | |||
| 2 | INN | Class | Route (list) | PK parameters= Cmax; Tmax; F: bioavailability; t1/2: half-life; VD: volume of distribution; Cl: clearance; PPB: plasma protein binding;(EQN means that value was calculated using VD=(Cl*t1/2)/0.693) | Primary Target and PDB code of Protein-Drug complex | Targets from DrugCentral | Links | |||
| ETOPOSIDE PHOSPHATE (has an active metabolite)
| ETOPOSIDE PHOSPHATE | ANTINEOPLASTIC | INJECTION | SOLUBILITY WATER SOLUBLE ESTER OF ETOPOSIDE | DNA TOPOISOMERASE 2 | DNA topoisomerase 2-alpha UNIPROT P11388 TOP2A more at DrugCentral | EMA | |||
