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| 1 | INN | Class | Route (list) | PK parameters= Cmax; Tmax; F: bioavailability; t1/2: half-life; VD: volume of distribution; Cl: clearance; PPB: plasma protein binding;(EQN means that value was calculated using VD=(Cl*t1/2)/0.693) | Primary Target and PDB code of Protein-Drug complex | Targets from DrugCentral | Links | |||
| MILNACIPRAN
| MILNACIPRAN | NERVOUS SYSTEM | ORAL | Tmax 3 HOUR F 87.5 PERCENT VD 400 LITER PPB 13 PERCENT Cl 39.6 LITER / HOUR (EQN) HT 7 HOUR SOLUBILITY FREELY SOLUBLE IN WATER | SEROTONIN TRANSPORTER NOREPINEPHRINE TRANSPORTER PDB 6M3Z (X-RAY STRUCTURE OF A DROSOPHILA DOPAMINE TRANSPORTER WITH NET-LIKE MUTATIONS (D121G, S426M, F471L) IN MILNACIPRAN BOUND FORM) LIGAND CODE = F0F (link to the list of PDB complexes) Download experimental 3D coordinates of F0F with added hydrogens | Sodium-dependent serotonin transporter UNIPROT P31645 SLC6A4 -- Sodium-dependent noradrenaline transporter UNIPROT P23975 SLC6A2 more at DrugCentral | EMA | |||
