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1 INNClassRoute (list)PK parameters= Cmax; Tmax; F: bioavailability; t1/2: half-life; VD: volume of distribution; Cl: clearance; PPB: plasma protein binding;(EQN means that value was calculated using VD=(Cl*t1/2)/0.693)Primary Target and PDB code of Protein-Drug complexTargets from DrugCentral Links
MILNACIPRAN

MILNACIPRAN


ATC N06AX17

NERVOUS SYSTEM
TREATMENT OF MAJOR DEPRESSIVE DISORDER
SEROTONIN (KI=11 NANOMOLAR) AND NOREPINEPHRINE (KI=91 NANOMOLAR) REUPTAKE INHIBITOR (SNRI)
MANAGEMENT OF FIBROMYALGIA

ORAL

Tmax 3 HOUR

F 87.5 PERCENT

VD 400 LITER

PPB 13 PERCENT

Cl 39.6 LITER / HOUR (EQN)

HT 7 HOUR

SOLUBILITY FREELY SOLUBLE IN WATER

SEROTONIN TRANSPORTER
NOREPINEPHRINE TRANSPORTER

PDB 6M3Z (X-RAY STRUCTURE OF A DROSOPHILA DOPAMINE TRANSPORTER WITH NET-LIKE MUTATIONS (D121G/S426M/F471L) IN MILNACIPRAN BOUND FORM)

LIGAND CODE = F0F (link to the list of PDB complexes)

Download experimental 3D coordinates of F0F with added hydrogens

NOREPINEPHRINE TRANSPORTER INHIBITOR CHEMBL222 NOREPINEPHRINE TRANSPORTER P23975 SODIUM-DEPENDENT NORADRENALINE TRANSPORTER HOMO SAPIENS TRANSPORTER ELECTROCHEMICAL SLC SLC06ANSM (in French)

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