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| 1 | INN | Class | Route (list) | PK parameters= Cmax; Tmax; F: bioavailability; t1/2: half-life; VD: volume of distribution; Cl: clearance; PPB: plasma protein binding;(EQN means that value was calculated using VD=(Cl*t1/2)/0.693) | Primary Target and PDB code of Protein-Drug complex | Targets from DrugCentral | Links | |||
| ISOTRETINOIN
| ISOTRETINOIN |
DERMATOLOGICALS | ORAL | Cmax 2.87 MICROMOLAR Tmax 5.3 HOUR PPB 99.9 PERCENT HT 21 HOUR SOLUBILITY PRACTICALLY INSOLUBLE IN WATER | RETINOIC ACID RECEPTOR ALPHA PDB 1GX9 (BOVINE BETA-LACTOGLOBULIN COMPLEXED WITH RETINOIC ACID, TRIGONAL LATTICE Z) LIGAND CODE = REA (link to the list of PDB complexes) Download experimental 3D coordinates of REA with added hydrogens | Retinoic acid receptor beta UNIPROT P10826 RARB more at DrugCentral | EMA | |||
