Cheminformatic Tools and Databases for Pharmacology

session 65800 - Total of 1 hits - Display   hits per page:

Add another drug(s) by one keyword:
Exemple: “nib“ and click on the Search button (do not press Enter on the keyboard)

1 INNClassRoute (list)PK parameters= Cmax; Tmax; F: bioavailability; t1/2: half-life; VD: volume of distribution; Cl: clearance; PPB: plasma protein binding;(EQN means that value was calculated using VD=(Cl*t1/2)/0.693)Primary Target and PDB code of Protein-Drug complexTargets from DrugCentral Links
MIDAZOLAM

MIDAZOLAM


ATC N05CD08

NERVOUS SYSTEM
ANESTHETIC
ANTI-ANXIETY AGENTS
GABA MODULATORS
HYPNOTICS AND SEDATIVES
BENZODIAZEPINE
TREATMENT OF CONVULSIVE SEIZURES (EPILEPSY)

INJECTION ORAL INTRAMUSCULAR NASAL INTRAVENOUS

Cmax 276.5 NANOMOLAR

Tmax 0.5 HOUR

F 90 PERCENT

VD 133.2 LITER (65 KILOGRAM)

PPB 97 PERCENT

Cl 25.6 LITER / HOUR (65 KILOGRAM)

HT 4.1 HOUR

SOLUBILITY INSOLUBLE IN WATER

GAMMA-AMINOBUTYRIC-ACID RECEPTOR

PDB 5TE8 (CRYSTAL STRUCTURE OF THE MIDAZOLAM-BOUND HUMAN CYP3A4)

LIGAND CODE = 08J (link to the list of PDB complexes)

Download experimental 3D coordinates of 08J with added hydrogens

GABA-A RECEPTOR ANION CHANNEL POSITIVE ALLOSTERIC MODULATOR CHEMBL2093872 GABA-A RECEPTOR ANION CHANNEL P14867 GAMMA-AMINOBUTYRIC ACID RECEPTOR SUBUNIT ALPHA-1 HOMO SAPIENS ION CHANNEL LGIC GABAAANSM (in French)

Dailymed
Drugs.com

SIDER side effects

Chemical Probes Portal

ChEMBL
BindingDB
DrugBank



Copyright © 2019 Université Côte d'Azur CNRS - All rights reserved
  | Contact |