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| 1 | INN | Class | Route (list) | PK parameters= Cmax; Tmax; F: bioavailability; t1/2: half-life; VD: volume of distribution; Cl: clearance; PPB: plasma protein binding;(EQN means that value was calculated using VD=(Cl*t1/2)/0.693) | Primary Target and PDB code of Protein-Drug complex | Targets from DrugCentral | Links | |||
| PENTOXIFYLLINE
| PENTOXIFYLLINE | CARDIOVASCULAR | ORAL | Tmax 1 HOUR VD 117 LITER (65 KILOGRAM) Cl 152 LITER / HOUR (65 KILOGRAM) HT 0.6 HOUR SOLUBILITY SOLUBLE IN WATER | PHOSPHODIESTERASE PDB 3ARR (CRYSTAL STRUCTURE ANALYSIS OF CHITINASE A FROM VIBRIO HARVEYI WITH NOVEL INHIBITORS - COMPLEX STRUCTURE WITH PENTOXIFYLLINE) LIGAND CODE = PNX (link to the list of PDB complexes) Download experimental 3D coordinates of PNX with added hydrogens | Adenosine receptor A2b UNIPROT P29275 ADORA2B -- cAMP-specific 3,5-cyclic phosphodiesterase 4B UNIPROT Q07343 PDE4B more at DrugCentral | EMA | |||
