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| 1 | INN | Class | Route (list) | PK parameters= Cmax; Tmax; F: bioavailability; t1/2: half-life; VD: volume of distribution; Cl: clearance; PPB: plasma protein binding;(EQN means that value was calculated using VD=(Cl*t1/2)/0.693) | Primary Target and PDB code of Protein-Drug complex | Targets from DrugCentral | Links | |||
| ACYCLOVIR (is an active metabolite) (has an active metabolite)
| ACYCLOVIR | ANTIINFECTIVES | INJECTION TOPICAL ORAL BUCCAL OPHTHALMIC | Cmax 107 MICROMOLAR F 15 PERCENT VD 46 LITER (65 KILOGRAM) PPB 21 PERCENT Cl 19.9 LITER / HOUR (65 KILOGRAM) HT 2.5 HOUR SOLUBILITY 100 MILLIGRAM / MILLILITER IN WATER | THYMIDINE KINASE PDB 5I3C (CRYSTAL STRUCTURE OF E.COLI PURINE NUCLEOSIDE PHOSPHORYLASE WITH ACYCLOGUANOSINE) LIGAND CODE = AC2 (link to the list of PDB complexes) Download experimental 3D coordinates of AC2 with added hydrogens | DNA polymerase catalytic subunit UNIPROT P04293 -- DNA polymerase catalytic subunit UNIPROT P09252 more at DrugCentral | EMA | |||
