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1 INNClassRoute (list)PK parameters= Cmax; Tmax; F: bioavailability; t1/2: half-life; VD: volume of distribution; Cl: clearance; PPB: plasma protein binding;(EQN means that value was calculated using VD=(Cl*t1/2)/0.693)Primary Target and PDB code of Protein-Drug complexTargets from DrugCentral Links
BUPROPION

BUPROPION


ATC N06AX12
ATC A08AA62

NERVOUS SYSTEM
ANTIDEPRESSANT
NON-NICOTINE AID TO SMOKING CESSATION
WEAK DOPAMINE AND NOREPINEPHRINE UPTAKE INHIBITORS
AMINOKETONE

ORAL

Cmax 597 NANOMOLAR

Tmax 2 HOUR

VD 1950 LITER

PPB 84 PERCENT

Cl 209 LITER / HOUR

HT 21 HOUR

SOLUBILITY HIGHLY SOLUBLE IN WATER

DOPAMINE TRANSPORTER
NOREPINEPHRINE TRANSPORTER

NOREPINEPHRINE TRANSPORTER INHIBITOR CHEMBL222 NOREPINEPHRINE TRANSPORTER P23975 SODIUM-DEPENDENT NORADRENALINE TRANSPORTER HOMO SAPIENS TRANSPORTER ELECTROCHEMICAL SLC SLC06ANSM (in French)

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