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| 1 | INN | Class | Route (list) | PK parameters= Cmax; Tmax; F: bioavailability; t1/2: half-life; VD: volume of distribution; Cl: clearance; PPB: plasma protein binding;(EQN means that value was calculated using VD=(Cl*t1/2)/0.693) | Primary Target and PDB code of Protein-Drug complex | Targets from DrugCentral | Links | |||
| KETOCONAZOLE
| KETOCONAZOLE |
ANTIINFECTIVES | ORAL TOPICAL | Cmax 6.5 MICROMOLAR (PMID18621671) Tmax 1.5 HOUR PPB 99 PERCENT HT 6.5 HOUR SOLUBILITY REQUIRES ACIDITY FOR DISSOLUTION | CYTOCHROME P450 51 PDB 6AYB (NAEGLERIA FOWLERI CYP51-KETOCONAZOLE COMPLEX) LIGAND CODE = KKK (link to the list of PDB complexes) Download experimental 3D coordinates of KKK with added hydrogens | Lanosterol 14-alpha demethylase UNIPROT P10613 ERG11 -- Steroid 17-alpha-hydroxylase,17,20 lyase UNIPROT P05093 CYP17A1 more at DrugCentral | EMA | |||
