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1 INNClassRoute (list)PK parameters= Cmax; Tmax; F: bioavailability; t1/2: half-life; VD: volume of distribution; Cl: clearance; PPB: plasma protein binding;(EQN means that value was calculated using VD=(Cl*t1/2)/0.693)Primary Target and PDB code of Protein-Drug complexTargets from DrugCentral Links
KETOCONAZOLE

KETOCONAZOLE


ATC D01AC08
ATC G01AF11
ATC J02AB02

ANTIINFECTIVES
ANTIFUNGAL
OPICAL TREATMENT OF SEBORRHEIC DERMATITIS
IMPAIRS BIOSYNTHESIS OF ERGOSTEROL

ORAL TOPICAL

Cmax 6.5 MICROMOLAR (PMID18621671)

Tmax 1.5 HOUR

PPB 99 PERCENT

HT 6.5 HOUR

SOLUBILITY REQUIRES ACIDITY FOR DISSOLUTION

CYTOCHROME P450 51

PDB 6AYB (NAEGLERIA FOWLERI CYP51-KETOCONAZOLE COMPLEX)

LIGAND CODE = KKK (link to the list of PDB complexes)

Download experimental 3D coordinates of KKK with added hydrogens

STEROID 17-ALPHA-HYDROXYLASE/17,20 LYASE P05093 STEROID 17-ALPHA-HYDROXYLASE/17,20 LYASE HOMO SAPIENS ENZYME CYTOCHROME P450 CYP_17 CYP_17A CYP_17A1ANSM (in French)

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