| | ||||||||||
| 1 | INN | Class | Route (list) | PK parameters= Cmax; Tmax; F: bioavailability; t1/2: half-life; VD: volume of distribution; Cl: clearance; PPB: plasma protein binding;(EQN means that value was calculated using VD=(Cl*t1/2)/0.693) | Primary Target and PDB code of Protein-Drug complex | Targets from DrugCentral | Links | |||
| NITROGLYCERIN
| NITROGLYCERIN |
CARDIOVASCULAR | INJECTION SUBLINGUAL TRANSDERMAL INTRA | Cmax 4.5 NANOMOLAR Tmax 0.125 HOUR F 40 PERCENT VD 214.5 LITER (65 KILOGRAM) PPB 60 PERCENT Cl 816 LITER / HOUR HT 0.046 HOUR | PDB 4FR8 (CRYSTAL STRUCTURE OF HUMAN ALDEHYDE DEHYDROGENASE-2 IN COMPLEX WITH NITROGLYCERIN) LIGAND CODE = TNG (link to the list of PDB complexes) Download experimental 3D coordinates of TNG with added hydrogens | Soluble guanylate cyclase UNIPROT O75343 GUCY1B2 more at DrugCentral | EMA | |||
