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1 INNClassRoute (list)PK parameters= Cmax; Tmax; F: bioavailability; t1/2: half-life; VD: volume of distribution; Cl: clearance; PPB: plasma protein binding;(EQN means that value was calculated using VD=(Cl*t1/2)/0.693)Primary Target and PDB code of Protein-Drug complexTargets from DrugCentral Links
VERAPAMIL

VERAPAMIL


ATC C09BB10
ATC C08DA01
ATC C08DA51

CARDIOVASCULAR
CALCIUM ION INFLUX INHIBITOR
L-TYPE CALCIUM CHANNEL BLOCKER
CORONARY VASODILATOR
ANTIARRHYTHMIC

INJECTION ORAL INTRAVENOUS

Cmax 881 NANOMOLAR

Tmax 1.5 HOUR

F 13 PERCENT

VD 240.5 LITER (65 KILOGRAM)

PPB 90 PERCENT

Cl 70.2 LITER / HOUR (65 KILOGRAM)

HT 5.1 HOUR

SOLUBILITY SOLUBLE IN WATER

VOLTAGE-DEPENDENT CALCIUM CHANNEL

PDB 7QKR (CRYO-EM STRUCTURE OF ABC TRANSPORTER STE6-2P FROM PICHIA PASTORIS WITH VERAPAMIL AT 3.2 A RESOLUTION)

LIGAND CODE = I6H (link to the list of PDB complexes)

Download experimental 3D coordinates of I6H with added hydrogens

Voltage-dependent L-type calcium channel subunit alpha-1C UNIPROT Q13936 CACNA1C -- Voltage-dependent L-type calcium channel subunit alpha-1S UNIPROT Q13698 CACNA1S

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