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| 1 | INN | Class | Route (list) | PK parameters= Cmax; Tmax; F: bioavailability; t1/2: half-life; VD: volume of distribution; Cl: clearance; PPB: plasma protein binding;(EQN means that value was calculated using VD=(Cl*t1/2)/0.693) | Primary Target and PDB code of Protein-Drug complex | Targets from DrugCentral | Links | |||
| OXYMETAZOLINE
| OXYMETAZOLINE |
RESPIRATORY SYSTEM | OPHTHALMIC NASAL TOPICAL | ALPHA-2A ADRENERGIC RECEPTOR ALPHA-1A ADRENERGIC RECEPTOR PDB 7EJK (STRUCTURE OF THE ALPHA2A-ADRENERGIC RECEPTOR GOA SIGNALING COMPLEX BOUND TO OXYMETAZOLINE) LIGAND CODE = J5C (link to the list of PDB complexes) Download experimental 3D coordinates of J5C with added hydrogens | Alpha-1A adrenergic receptor UNIPROT P35348 ADRA1A -- Alpha-2B adrenergic receptor UNIPROT P18089 ADRA2B more at DrugCentral | EMA | ||||
