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1 INNClassRoute (list)PK parameters= Cmax; Tmax; F: bioavailability; t1/2: half-life; VD: volume of distribution; Cl: clearance; PPB: plasma protein binding;(EQN means that value was calculated using VD=(Cl*t1/2)/0.693)Primary Target and PDB code of Protein-Drug complexTargets from DrugCentral Links
DIFLUNISAL

DIFLUNISAL


ATC N02BA11

NERVOUS SYSTEM
ANTIINFLAMMATORY
ANALGESIC
NSAID
CYCLOOXYGENASE INHIBITORS
SYMPTOMATIC TREATMENT OF MILD TO MODERATE PAIN, OSTEOARTHRITIS AND RHEUMATOID ARTHRITIS
ANTIPYRETIC

ORAL

Cmax 496 MICROMOLAR

Tmax 2.5 HOUR

VD 6.3 LITER (65 KILOGRAM)

PPB 99 PERCENT

Cl 0.39 LITER / HOUR (65 KILOGRAM)

HT 10 HOUR

SOLUBILITY PRACTICALLY INSOLUBLE IN WATER

PROSTAGLANDIN G/H SYNTHASE 1
PROSTAGLANDIN G/H SYNTHASE 2

PDB 4I89 (CRYSTAL STRUCTURE OF TRANSTHYRETIN IN COMPLEX WITH DIFLUNISAL AT ACIDIC PH)

LIGAND CODE = 1FL (link to the list of PDB complexes)

Download experimental 3D coordinates of 1FL with added hydrogens

CYCLOOXYGENASE INHIBITOR CHEMBL2094253 CYCLOOXYGENASE P23219 PROSTAGLANDIN G/H SYNTHASE 1 HOMO SAPIENS ENZYME REDUCTASEANSM (in French)

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