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1 INNClassRoute (list)PK parameters= Cmax; Tmax; F: bioavailability; t1/2: half-life; VD: volume of distribution; Cl: clearance; PPB: plasma protein binding;(EQN means that value was calculated using VD=(Cl*t1/2)/0.693)Primary Target and PDB code of Protein-Drug complexTargets from DrugCentral Links
GEMFIBROZIL

GEMFIBROZIL


ATC C10AB04

CARDIOVASCULAR
HYPOLIPIDEMIC
FRIBIC ACID DERIVATIVES
STIMULATING THE EXPRESSION OF MYELIN-SPECIFIC GENES

ORAL

Cmax 184 MICROMOLAR

Tmax 1.5 HOUR

F 100 PERCENT

VD 11 LITER

PPB 98 PERCENT

Cl 7.8 LITER / HOUR

HT 1.5 HOUR

SOLUBILITY PRACTICALLY INSOLUBLE IN WATER (IN ACID IS 0.0019 PERCENT)

PEROXISOME PROLIFERATOR-ACTIVATED RECEPTOR ALPHA

PDB 5BOJ (CRYSTAL STRUCTURE OF HUMAN TRANSTHYRETIN IN COMPLEX WITH GEMFIBROZIL)

LIGAND CODE = 4TX (link to the list of PDB complexes)

Download experimental 3D coordinates of 4TX with added hydrogens

PEROXISOME PROLIFERATOR-ACTIVATED RECEPTOR ALPHA AGONIST CHEMBL239 PEROXISOME PROLIFERATOR-ACTIVATED RECEPTOR ALPHA Q07869 PEROXISOME PROLIFERATOR-ACTIVATED RECEPTOR ALPHA HOMO SAPIENS TRANSCRIPTION FACTOR NUCLEAR RECEPTOR NR1 NR1C NR1C1ANSM (in French)

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