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1 INNClassRoute (list)PK parameters= Cmax; Tmax; F: bioavailability; t1/2: half-life; VD: volume of distribution; Cl: clearance; PPB: plasma protein binding;(EQN means that value was calculated using VD=(Cl*t1/2)/0.693)Primary Target and PDB code of Protein-Drug complexTargets from DrugCentral Links
BUPRENORPHINE

BUPRENORPHINE


ATC N02AE01
ATC N07BC01
ATC N07BC51

NERVOUS SYSTEM
ANALGESIC
NARCOTIC ANTAGONISTS
TREATMENT OF OPIOID DEPENDENCE
MU-TYPE OPIOID RECEPTOR PARTIAL AGONIST
KAPPA-TYPE OPIOID RECEPTOR ANTAGONIST

INJECTION SUBLINGUAL TRANSDERMAL BUCCAL IMPLANTATION SUBCUTANEOUS

Cmax 10 NANOMOLAR

Tmax 1.42 HOUR

F 15 PERCENT

VD 430 LITER

PPB 96 PERCENT

Cl 55 LITER / HOUR

HT 36.5 HOUR

SOLUBILITY SPARINGLY SOLUBLE IN WATER

KAPPA-TYPE OPIOID RECEPTOR
MU-TYPE OPIOID RECEPTOR

MU OPIOID RECEPTOR AGONIST CHEMBL233 MU OPIOID RECEPTOR P35372 MU-TYPE OPIOID RECEPTOR HOMO SAPIENS MEMBRANE RECEPTOR 7TM1 PEPTIDE SHORT PEPTIDE OPIOID RECEPTORANSM (in French)

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