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| 1 | INN | Class | Route (list) | PK parameters= Cmax; Tmax; F: bioavailability; t1/2: half-life; VD: volume of distribution; Cl: clearance; PPB: plasma protein binding;(EQN means that value was calculated using VD=(Cl*t1/2)/0.693) | Primary Target and PDB code of Protein-Drug complex | Targets from DrugCentral | Links | |||
| ALPRAZOLAM
| ALPRAZOLAM | NERVOUS SYSTEM | ORAL | Cmax 119.9 NANOMOLAR Tmax 1.5 HOUR F 90 PERCENT VD 52 LITER (65 KILOGRAM) PPB 80 PERCENT Cl 2.88 LITER / HOUR (65 KILOGRAM) HT 11.2 HOUR SOLUBILITY NO APPRECIABLE SOLUBILITY IN WATER | GAMMA-AMINOBUTYRIC-ACID RECEPTOR PDB 3U5J (CRYSTAL STRUCTURE OF THE FIRST BROMODOMAIN OF HUMAN BRD4 IN COMPLEX WITH ALPRAZOLAM) LIGAND CODE = 08H (link to the list of PDB complexes) Download experimental 3D coordinates of 08H with added hydrogens | GABA-A receptor alpha-1,beta-2,gamma-2 UNIPROT P14867 GABRA1 -- GABA-A receptor alpha-2,beta-3,gamma-2 UNIPROT P18507 GABRG2 more at DrugCentral | EMA | |||
