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1 INNClassRoute (list)PK parameters= Cmax; Tmax; F: bioavailability; t1/2: half-life; VD: volume of distribution; Cl: clearance; PPB: plasma protein binding;(EQN means that value was calculated using VD=(Cl*t1/2)/0.693)Primary Target and PDB code of Protein-Drug complexTargets from DrugCentral Links
ETOMIDATE

ETOMIDATE


ATC N01AX07

NERVOUS SYSTEM
HYPNOTIC
ANXIOLYTIC
SEDATIVES

INJECTION

VD 175.5 LITER (65 KILOGRAM)

PPB 76 PERCENT

Cl 50.7 LITER / HOUR (65 KILOGRAM)

HT 1.25 HOUR

GAMMA-AMINOBUTYRIC-ACID RECEPTOR

PDB 6X3V (HUMAN GABAA RECEPTOR ALPHA1-BETA2-GAMMA2 SUBTYPE IN COMPLEX WITH GABA PLUS ETOMIDATE)

LIGAND CODE = V8D (link to the list of PDB complexes)

Download experimental 3D coordinates of V8D with added hydrogens

GABA-A RECEPTOR ANION CHANNEL POSITIVE MODULATOR CHEMBL2093872 GABA-A RECEPTOR ANION CHANNEL O00591 GAMMA-AMINOBUTYRIC ACID RECEPTOR SUBUNIT PI HOMO SAPIENS ION CHANNEL LGIC GABAAANSM (in French)

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