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| 1 | INN | Class | Route (list) | PK parameters= Cmax; Tmax; F: bioavailability; t1/2: half-life; VD: volume of distribution; Cl: clearance; PPB: plasma protein binding;(EQN means that value was calculated using VD=(Cl*t1/2)/0.693) | Primary Target and PDB code of Protein-Drug complex | Targets from DrugCentral | Links | |||
| ETOMIDATE
| ETOMIDATE | NERVOUS SYSTEM | INJECTION | VD 175.5 LITER (65 KILOGRAM) PPB 76 PERCENT Cl 50.7 LITER / HOUR (65 KILOGRAM) HT 1.25 HOUR | GAMMA-AMINOBUTYRIC-ACID RECEPTOR PDB 6X3V (HUMAN GABAA RECEPTOR ALPHA1-BETA2-GAMMA2 SUBTYPE IN COMPLEX WITH GABA PLUS ETOMIDATE) LIGAND CODE = V8D (link to the list of PDB complexes) Download experimental 3D coordinates of V8D with added hydrogens | GABA-A receptor alpha-1,beta-2,gamma-2 UNIPROT P14867 GABRA1 more at DrugCentral | EMA | |||
