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1 INNClassRoute (list)PK parameters= Cmax; Tmax; F: bioavailability; t1/2: half-life; VD: volume of distribution; Cl: clearance; PPB: plasma protein binding;(EQN means that value was calculated using VD=(Cl*t1/2)/0.693)Primary Target and PDB code of Protein-Drug complexTargets from DrugCentral Links
BUMETANIDE

BUMETANIDE


ATC C03CA02
ATC C03CB02
ATC C03EB02

CARDIOVASCULAR
DIURETIC
NA(+)-K(+)-2CL(-) COTRANSPORTER ISOFORM 1 INHIBITOR (PMID23788048)

ORAL INJECTION

Cmax 28.3 NANOMOLAR

Tmax 1.5 HOUR

VD 10.4 LITER (65 KILOGRAM)

PPB 95 PERCENT

Cl 11.3 LITER / HOUR (65 KILOGRAM)

HT 1.25 HOUR

SODIUM POTASSIUM CHLORIDE COTRANSPORTER (NKCC1)

SODIUM/POTASSIUM-TRANSPORTING ATPASE SUBUNIT ALPHA-1 P05023 SODIUM/POTASSIUM-TRANSPORTING ATPASE SUBUNIT ALPHA-1 HOMO SAPIENS ENZYME HYDROLASEANSM (in French)

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