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1 INNClassRoute (list)PK parameters= Cmax; Tmax; F: bioavailability; t1/2: half-life; VD: volume of distribution; Cl: clearance; PPB: plasma protein binding;(EQN means that value was calculated using VD=(Cl*t1/2)/0.693)Primary Target and PDB code of Protein-Drug complexTargets from DrugCentral Links
VALPROIC ACID

VALPROIC ACID
DIVALPROEX
VALPROATE


ATC N03AG01

NERVOUS SYSTEM
ANTICONVULSANT
ANTIMANIC AGENTS
INCREASE GAMMA-AMINO-BUTYRIC ACID (GABA)ERGIC TRANSMISSION

ORAL INJECTION

Cmax 563 MICROMOLAR

Tmax 3.5 HOUR

F 90 PERCENT

VD 11 LITER

PPB 82 PERCENT

Cl 0.56 LITER / HOUR

HT 12.5 HOUR

SOLUBILITY SLIGHTLY SOLUBLE IN WATER

Succinate-semialdehyde dehydrogenase, mitochondrial UNIPROT P51649 ALDH5A1

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