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1 INNClassRoute (list)PK parameters= Cmax; Tmax; F: bioavailability; t1/2: half-life; VD: volume of distribution; Cl: clearance; PPB: plasma protein binding;(EQN means that value was calculated using VD=(Cl*t1/2)/0.693)Primary Target and PDB code of Protein-Drug complexTargets from DrugCentral Links
AMOXAPINE

AMOXAPINE


ATC N06AA17

NERVOUS SYSTEM
ANTIDEPRESSANT
BLOCKS THE REUPTAKE OF NOREPINEPHRINE AND TO A LESSER EXTENT SEROTONIN INTO THEIR RESPECTIVE NEURONS
BLOCKS THE RESPONSE OF DOPAMINERGIC RECEPTORS TO DOPAMINE
ACTS ON MULTIPLE RECEPTORS AND CHANNELS (PMID24294487)

ORAL

Cmax 215 NANOMOLAR

Tmax 1.5 HOUR

PPB 90 PERCENT

HT 8 HOUR

DOPAMINE RECEPTOR ANTAGONIST CHEMBL2096905 DOPAMINE RECEPTOR P14416 D(2) DOPAMINE RECEPTOR HOMO SAPIENS MEMBRANE RECEPTOR 7TM1 SMALLMOL MONOAMINE RECEPTOR DOPAMINE RECEPTORANSM (in French)

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