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1 INNClassRoute (list)PK parameters= Cmax; Tmax; F: bioavailability; t1/2: half-life; VD: volume of distribution; Cl: clearance; PPB: plasma protein binding;(EQN means that value was calculated using VD=(Cl*t1/2)/0.693)Primary Target and PDB code of Protein-Drug complexTargets from DrugCentral Links
TIMOLOL

TIMOLOL


ATC C07AA06
ATC S01ED01
ATC C07BA06
ATC S01ED51
ATC C07DA06

CARDIOVASCULAR
NON-SELECTIVE BETA ADRENERGIC BLOCKER
ANTI-ARRHYTHMIA AGENTS
ANTIHYPERTENSIVE AGENTS
ANTIMIGRAINE
ANTIGLAUCOMA
ANTIANGINAL

ORAL OPHTHALMIC

Cmax 1.45 NANOMOLAR

VD 97.5 LITER (65 KILOGRAM)

PPB 10 PERCENT

Cl 33.1 LITER / HOUR (65 KILOGRAM)

HT 2.2 HOUR

SOLUBILITY SOLUBLE IN WATER

BETA-1 ADRENERGIC RECEPTOR
BETA-2 ADRENERGIC RECEPTOR

PDB 3D4S (CHOLESTEROL BOUND FORM OF HUMAN BETA2 ADRENERGIC RECEPTOR.)

LIGAND CODE = TIM (link to the list of PDB complexes)

Download experimental 3D coordinates of TIM with added hydrogens

BETA-2 ADRENERGIC RECEPTOR ANTAGONIST CHEMBL210 BETA-2 ADRENERGIC RECEPTOR P07550 BETA-2 ADRENERGIC RECEPTOR HOMO SAPIENS MEMBRANE RECEPTOR 7TM1 SMALLMOL MONOAMINE RECEPTOR ADRENERGIC RECEPTORANSM (in French)

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