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1 INNClassRoute (list)PK parameters= Cmax; Tmax; F: bioavailability; t1/2: half-life; VD: volume of distribution; Cl: clearance; PPB: plasma protein binding;(EQN means that value was calculated using VD=(Cl*t1/2)/0.693)Primary Target and PDB code of Protein-Drug complexTargets from DrugCentral Links
SCOPOLAMINE

SCOPOLAMINENATURAL MOLECULE (link)


ATC A04AD01
ATC N05CM05
ATC S01FA02
ATC A04AD51

METABOLISM
ANTISPASMODIC
ANTICHOLINERGIC
ANTIMUSCARINICS
MYDRIATICS
A BELLADONNA ALKALOID
PREVENTION OF NAUSEA
NONSELECTIVE MUSCARINIC RECEPTOR ANTAGONIST

TRANSDERMAL

Cmax 906 NANOMOLAR (PMID2762223)

Tmax 4 HOUR

F 29.4 PERCENT

VD 201.5 LITER (65 KILOGRAM)

PPB 10 PERCENT (PMID9725548)

Cl 62.4 LITER / HOUR (65 KILOGRAM)

HT 9.5 HOUR

MUSCARINIC ACETYLCHOLINE RECEPTOR

PDB 8CVD (STRUCTURE OF HYOSCYAMINE 6-BETA HYDROXYLASE IN COMPLEX WITH IRON, SUCCINATE, AND SCOPOLAMINE)

LIGAND CODE = OW0 (link to the list of PDB complexes)

Download experimental 3D coordinates of OW0 with added hydrogens

Muscarinic acetylcholine receptor M1 UNIPROT P11229 CHRM1

more at DrugCentral

EMA

ANSM (in French)

Inxight Drugs
Dailymed
Drugs.com

SIDER side effects

Chemical Probes Portal

ChEMBL
BindingDB
DrugBank



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