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1 INNClassRoute (list)PK parameters= Cmax; Tmax; F: bioavailability; t1/2: half-life; VD: volume of distribution; Cl: clearance; PPB: plasma protein binding;(EQN means that value was calculated using VD=(Cl*t1/2)/0.693)Primary Target and PDB code of Protein-Drug complexTargets from DrugCentral Links
BUTORPHANOL

BUTORPHANOL


ATC N02AF01

NERVOUS SYSTEM
ANTITUSSIVE
ANALGESIC
NARCOTIC ANTAGONISTS
A MIXED AGONIST-ANTAGONIST OF MU-TYPE OPIOID RECEPTOR
AGONIST OF KAPPA-TYPE OPIOID RECEPTOR

INJECTION NASAL

Cmax 3.18 NANOMOLAR

Tmax 0.5 HOUR

F 65 PERCENT

VD 603 LITER

PPB 80 PERCENT

Cl 103 LITER / HOUR

HT 4.74 HOUR

KAPPA-TYPE OPIOID RECEPTOR
MU-TYPE OPIOID RECEPTOR

MU OPIOID RECEPTOR PARTIAL AGONIST CHEMBL233 MU OPIOID RECEPTOR P35372 MU-TYPE OPIOID RECEPTOR HOMO SAPIENS MEMBRANE RECEPTOR 7TM1 PEPTIDE SHORT PEPTIDE OPIOID RECEPTORANSM (in French)

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