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| 1 | INN | Class | Route (list) | PK parameters= Cmax; Tmax; F: bioavailability; t1/2: half-life; VD: volume of distribution; Cl: clearance; PPB: plasma protein binding;(EQN means that value was calculated using VD=(Cl*t1/2)/0.693) | Primary Target and PDB code of Protein-Drug complex | Targets from DrugCentral | Links | |||
| DINOPROSTONE
| DINOPROSTONE | GENITO | VAGINAL ENDOCERVICAL | Cmax 1.23 NANOMOLAR Tmax 0.62 HOUR HT 0.06 HOUR SOLUBILITY IN WATER 130 MILLIGRAM / 100 MILLILITER | PROSTAGLANDIN E2 RECEPTOR EP2 PDB 3WFH (CRYSTAL STRUCTURE OF ANTI-PROSTAGLANDIN E2 FAB FRAGMENT PGE2 COMPLEX) LIGAND CODE = P2E (link to the list of PDB complexes) Download experimental 3D coordinates of P2E with added hydrogens | Prostaglandin E2 receptor EP1 subtype UNIPROT P34995 PTGER1 -- Prostaglandin E2 receptor EP3 subtype UNIPROT P43115 PTGER3 more at DrugCentral | EMA | |||
