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| 1 | INN | Class | Route (list) | PK parameters= Cmax; Tmax; F: bioavailability; t1/2: half-life; VD: volume of distribution; Cl: clearance; PPB: plasma protein binding;(EQN means that value was calculated using VD=(Cl*t1/2)/0.693) | Primary Target and PDB code of Protein-Drug complex | Targets from DrugCentral | Links | |||
| ISOFLURANE
| ISOFLURANE | NERVOUS SYSTEM | INHALATION | CYS-LOOP FAMILY OF PENTAMERIC LIGAND-GATED ION CHANNELS (PLGIC) PDB 4Z90 (ELIC BOUND WITH THE ANESTHETIC ISOFLURANE IN THE RESTING STATE) LIGAND CODE = 4LE (link to the list of PDB complexes) Download experimental 3D coordinates of 4LE with added hydrogens | Potassium channel subfamily K member 2 UNIPROT O95069 KCNK2 -- Potassium channel subfamily K member 3 UNIPROT O14649 KCNK3 more at DrugCentral | EMA | ||||
