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1 INNClassRoute (list)PK parameters= Cmax; Tmax; F: bioavailability; t1/2: half-life; VD: volume of distribution; Cl: clearance; PPB: plasma protein binding;(EQN means that value was calculated using VD=(Cl*t1/2)/0.693)Primary Target and PDB code of Protein-Drug complexTargets from DrugCentral Links
CLOTRIMAZOLE

CLOTRIMAZOLE


ATC A01AB18
ATC D01AC01
ATC G01AF02

DERMATOLOGICALS
ANTIFUNGAL
ANTI-INFECTIVE
IMIDAZOLE
INHIBIT 14-ALPHA-DEMETHYLATION OF LANOSTEROL IN FUNGI

TOPICAL VAGINAL ORAL

Cmax 14 NANOMOLAR

Tmax 0.5 HOUR

SOLUBILITY INSOLUBLE IN WATER

CYTOCHROME P450 51

PDB 2XFH (STRUCTURE OF CYTOCHROME P450 ERYK COCRYSTALLIZED WITH INHIBITOR CLOTRIMAZOLE.)

LIGAND CODE = CL6 (link to the list of PDB complexes)

Download experimental 3D coordinates of CL6 with added hydrogens

CYTOCHROME P450 51 INHIBITOR CHEMBL1780 CYTOCHROME P450 51 P10613 LANOSTEROL 14-ALPHA DEMETHYLASE CANDIDA ALBICANS (STRAIN SC5314 / ATCC MYA-2876) (YEAST) ENZYME CYTOCHROME P450 CYP_51 CYP_51A CYP_51A1ANSM (in French)

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