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| 1 | INN | Class | Route (list) | PK parameters= Cmax; Tmax; F: bioavailability; t1/2: half-life; VD: volume of distribution; Cl: clearance; PPB: plasma protein binding;(EQN means that value was calculated using VD=(Cl*t1/2)/0.693) | Primary Target and PDB code of Protein-Drug complex | Targets from DrugCentral | Links | |||
| NAPROXEN
| NAPROXEN |
MUSCULO-SKELETAL | ORAL | Cmax 423 MICROMOLAR Tmax 3 HOUR F 95 PERCENT VD 10.4 LITER (65 KILOGRAM) PPB 99 PERCENT Cl 0.507 LITER / HOUR (65 KILOGRAM) HT 14.5 HOUR SOLUBILITY FREELY SOLUBLE IN WATER AT NEUTRAL PH (LOGP = 1.6) | PROSTAGLANDIN G/H SYNTHASE 1 PROSTAGLANDIN G/H SYNTHASE 2 PDB 4OR0 (CRYSTAL STRUCTURE OF BOVINE SERUM ALBUMIN IN COMPLEX WITH NAPROXEN) LIGAND CODE = NPS (link to the list of PDB complexes) Download experimental 3D coordinates of NPS with added hydrogens | Prostaglandin G,H synthase 2 UNIPROT P35354 PTGS2 -- Prostaglandin G,H synthase 1 UNIPROT P23219 PTGS1 more at DrugCentral | EMA | |||
