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| 1 | INN | Class | Route (list) | PK parameters= Cmax; Tmax; F: bioavailability; t1/2: half-life; VD: volume of distribution; Cl: clearance; PPB: plasma protein binding;(EQN means that value was calculated using VD=(Cl*t1/2)/0.693) | Primary Target and PDB code of Protein-Drug complex | Targets from DrugCentral | Links | |||
| DANAZOL
| DANAZOL | GENITO | ORAL | Cmax 206 NANOMOLAR Tmax 4 HOUR VD 10175 LITER (EQN) Cl 727 LITER / HOUR HT 9.7 HOUR SOLUBILITY INSOLUBLE IN WATER | ESTROGEN RECEPTOR PROGESTERONE RECEPTOR ANDROGEN RECEPTOR PDB 6ULB (SEX HORMONE-BINDING GLOBULIN MUTANT E176K IN COMPLEX WITH DANAZOL) LIGAND CODE = QA1 (link to the list of PDB complexes) Download experimental 3D coordinates of QA1 with added hydrogens | Androgen receptor UNIPROT P10275 AR -- Progesterone receptor UNIPROT P06401 PGR more at DrugCentral | EMA | |||
