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| 1 | INN | Class | Route (list) | PK parameters= Cmax; Tmax; F: bioavailability; t1/2: half-life; VD: volume of distribution; Cl: clearance; PPB: plasma protein binding;(EQN means that value was calculated using VD=(Cl*t1/2)/0.693) | Primary Target and PDB code of Protein-Drug complex | Targets from DrugCentral | Links | |||
| CARBIDOPA
| CARBIDOPA | NERVOUS SYSTEM | ORAL ENTERAL | Cmax 995 NANOMOLAR Tmax 2.95 HOUR F 99 PERCENT PPB 36 PERCENT HT 1.8 HOUR SOLUBILITY SLIGHTLY SOLUBLE IN WATER | AROMATIC-L-AMINO-ACID DECARBOXYLASE (AADC) PDB 1JS3 (CRYSTAL STRUCTURE OF DOPA DECARBOXYLASE IN COMPLEX WITH THE INHIBITOR CARBIDOPA) LIGAND CODE = 142 (link to the list of PDB complexes) Download experimental 3D coordinates of 142 with added hydrogens | Aromatic-L-amino-acid decarboxylase UNIPROT P20711 DDC more at DrugCentral | EMA | |||
