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1 INNClassRoute (list)PK parameters= Cmax; Tmax; F: bioavailability; t1/2: half-life; VD: volume of distribution; Cl: clearance; PPB: plasma protein binding;(EQN means that value was calculated using VD=(Cl*t1/2)/0.693)Primary Target and PDB code of Protein-Drug complexTargets from DrugCentral Links
CARBIDOPA

CARBIDOPA

NERVOUS SYSTEM
ENZYME INHIBITOR (DECARBOXYLASE)
ANTIDYSKINETICS
ANTIPARKINSON AGENTS

ORAL ENTERAL

Cmax 995 NANOMOLAR

Tmax 2.95 HOUR

F 99 PERCENT

PPB 36 PERCENT

HT 1.8 HOUR

SOLUBILITY SLIGHTLY SOLUBLE IN WATER

AROMATIC-L-AMINO-ACID DECARBOXYLASE (AADC)

PDB 1JS3 (CRYSTAL STRUCTURE OF DOPA DECARBOXYLASE IN COMPLEX WITH THE INHIBITOR CARBIDOPA)

LIGAND CODE = 142 (link to the list of PDB complexes)

Download experimental 3D coordinates of 142 with added hydrogens

DOPA DECARBOXYLASE INHIBITOR CHEMBL1843 DOPA DECARBOXYLASE P20711 AROMATIC-L-AMINO-ACID DECARBOXYLASE HOMO SAPIENS ENZYME LYASEANSM (in French)

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